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Slide tutorial – case 3
Clinical history: 56yo male – Enlarged left groin node.
Digital slide: H&E (x 40 scan) – Review before progressing
Macroscopic and microscopic images:
- Low power with node effacement
- Medium power with node effacement
- Effaced node and high endothelial vessels
- High power with constituent cells
- IHC – CD3
- IHC – CD5
- IHC – CD20
- IHC – CD30
- IHC – ALK
- IHC – Ki67
Diagnosis:
Video tutorial
Case discussion
This is an important case because it;
- illustrates the pathological features of an important condition
- requires development of an approached to an effaced node with atypical lymphoid population
The key features to take away include;
- Low power lymph node architectural effacement
- Cellular components and morphology in T-cell lymphoma (neoplastic and non-neoplastic)
- Important immunostains in T-cell lymphoma and it’s differential diagnoses
Extended learning topics
Outline your approach to an effaced lymph node with large atypical cells – including rational immunohistochemical panel
Discuss EBV-related disease (Not specific to this case but and important topic nonetheless)
Drop me a line or call me at TissuPath if you want to discuss any of these cases further
Andrew
This case has been de-identified and is intended for educational purposes only
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