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Slide tutorial – case 4
Clinical history: 20yo female – Left renal tumour.
Digital slide: H&E (x 40 scan) – Review before progressing
Macroscopic and microscopic images:
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- Macroscopic appearance of left kidney lesion
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- Low power
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- Medium power
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- Lesion architecture
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- Focal lesional adipose tissue
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- Epitheliod cells
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- DDx includes oncocytoma
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- IHC – HMB45
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- IHC – Melan A
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- IHC – CK7
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- IHC – CD10
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- IHC – Vimentin
Diagnosis:
Video tutorial
Case discussion
This is an important case because it;
- illustrates the pathological features of an important but rare neoplastic condition
- requires development of an approached to lesions of the kidney with abundant eosinophilic cytoplasm
- raises the management of cases with ambiguous/failed immunohistochemical staining
The key features to take away include;
- H&E morphology of AML and in particular epitheliod AML
- Relevant immunohistochemical panel in this setting
- How to manage ambiguous/failed immunohistochemical staining
Extended learning topics
Outline your differential diagnosis fro an ‘eosinophilic’ lesion of the kidney
Discuss tuberous sclerosis, addressing aetiology and the spectrum of disease seen in this condition
Drop me a line or call me at TissuPath if you want to discuss any of these cases further
Andrew
This case has been de-identified and is intended for educational purposes only
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