Author Archive

Tumour Volume in prostate cancer: Some more evidence for it’s importance.

TissuPath research

We were recently chatting amongst ourselves about the link between calculated tumour volume and pathological variables known to be prognostically significant (eg. extraprostatic extension (EPE), positive pathological margins etc). One of the things raised was whether there was any identifiable breakpoints or specific relationship between tumour volume and these adverse pathological variables. As part of a […]

Colorectal carcinoma, extramural spread and TNM staging

Tissue dissection

Case notes: 80y.o. male with abdominal pain and obstructive symptoms. Right hemicolectomy. Macroscopic assessment: Ulcerated tumour,  110 x 70mm, in the ascending colon/hepatic flexure,  with extensive invasion into pericolic fat and subserosa and multiple separate pericolic tumour nodules. Microscopic: Poorly differentiated adenocarcinoma, multifocal lymphovascular invasion including extramural venous invasion, extension to free serosal surface, metastatic carcinoma in […]

TissuPath research update ~ April 2012

TissuPath research

TissuPath is committed to medical and scientific research, with a special focus on prostate cancer.  Our prostate cancer research is focused on using  information obtained from pathology review and additional analysis, in an attempt to identify “good” or “bad” prostate cancers, with the aim of improving the ability of surgeons and other clinicians in managing […]

Transcoelomic spread of tumour and ‘omental cake’

Clinical notes: 80 yo female presents with large bowel obstruction, 12 months after a hysterectomy for endometrial carcinoma. Macroscopic: A sheet of omental adopse tissue with a central broad, grey, firm plaque 50 x 25mm. Microscopic: The omemental adipose tissue shows irregular, intersecting bands of fibrous tissue, within which are embedded angular to elongate glands […]

Let’s talk about margins ~ Urology education

Aims: Discuss and illustrate surgical margins, using radical prostatectomy specimen as an example. Discuss the difference between surgical and pathological margins Discussion: General Surgical margins are a contentious issue and ‘clear margins’ mean different things to a surgeon depending on the organ or disease being treated; in breast cancer, 10 mm is considered clearance while […]

The liver ~ Medical student education

THE LIVER: Aim To understand the basic anatomy and function of the liver To understand some of the common disease processes of the liver Discussion The liver is the highly complex metabolic engine of our body. It shares this duty with several other organs but is relatively unique in its ability to rapidly regenerate. Can you […]

Skin ~ Medical student education

Skin and common skin cancers Aim: Understand the structure and function of skin Understand the common tumours of the epidermis Discussion: Structure: Skin is made up of three discrete layers. The epidermis is formed by keratinocytes, which in cross section look like bricks in a brick wall (see picture below). The basal cells of this […]

Pathology case study 3 ~ Education

The following review of two separate cases illustrates a common kidney tumour. Both were small incidental findings discovered on CT. Both lesions originate around the capsule. Case 1 A51y.o. female underwent a partial nephrectomy. The specimen contained a circumscribed, pale grey nodule, 14mm in diameter that was clear of all margins.     Case 2 […]

Immunology ~ Medical student education

  Immunology: A simplified approach. Aims: Explain the concepts of  immunological surveillance Discuss the basic tools used by the inflammatory cells and Discuss hypersensitivity reactions to explain the different ways the immune response can work. Discussion: General The immune system has been with us since we were unicellular organisms. It has developed for two main […]

Pathology case study 2 ~ Education

A 54-year-old male presents with a PSA of 16.2 and a firm slightly enlarged prostate. Diagnosis: Xanthogranulomatous inflammation of the prostate Discussion: This is a relatively unusual condition but is important to recognize.  Clinically it often presents with a firm prostate associated with a high PSA.  This may reach above 20. Prostatitis is a contentious area. […]

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